乳腺癌组织中雌孕激素受体、c-erbB-2、p53、bcl-2及pS2的表达及意义

目的探讨乳腺癌组织中雌激素受体（ER）、孕激素受体（PR）、c-erbB-2、p53、bcl-2及pS2的表达及其临床意义。方法用免疫组织化学法检测75例乳腺癌标本中ER、PR、c-erbB-2、p53、bcl-2及pS2蛋白的表达情况,分析不同临床病理特征与其表达的关系。结果乳腺癌中ER、PR、C-erbB-2、p53、bcl-2和pS2的阳性表达率分别为74.7%、78.7%、49.3%、65.3%、82.7%和54.7%。PR的表达与患者年龄相关;p53的表达与组织学分级、病理类型、淋巴结转移、肿瘤位置和临床分期有关;bcl-2的表达与年龄、月经和肿瘤位置有关;pS2与绝经状况有关;bcl-2的表达与ER有关;ER（＋）、PR（＋）组中pS2阳性率明显高于ER（-）、PR（-）组（P〈0.05）。结论联合检测乳腺癌组织中ER、PR、c-erbB-2、p53、pS2及bcl-2蛋白的表达对于判断乳腺癌预后和指导治疗具有临床参考价值。

The expressions of ER, PR, c-erbB-2, p53, bcl-2 and pS2 in breast cancer tissues and their clinical significance

Objective To study the expressions of ER,PR,c-erbB-2,p53,bcl-2 and pS2 in breast cancer tissues and their clinical significance. Methods Immunohistochemistry method was used to analyze the expression of ER,PR,c-erbB-2,p53,bcl-2 and pS2 in 75 cases of breast cancers. Results Positive expression rates of ER,PR,c-erbB-2,p53,pS2 and bcl-2 in 75 cases of breast cancers were 74. 7% ,78. 7% ,49. 3% 65. 3% 82. 7% and 54. 7% respectively. The expression of PR was positive related to patient＇ s age. The expression of p53 was correlated with the histological grades,the pathological types,lymph node metastasis,the location of tumors and the clinical stage. The expression of p53 was correlated with menopause status. The expression of bcl-2 was positive related to the expression of ER. The positive expression rate of pS2 was significantly higher in ER and PR positive groups than in ER and PR negative groups. Conclusions Combined detection of expressions of ER,PR,c-erbB-2,p53,bcl-2 and pS2 in primary breast carcinoma has practical value in the evaluation of prognosis and therapeutic effects of breast cancer patients.