Systematic review on the role of serum tumor markers in the detection of recurrent pancreatic cancer |
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Authors: | Lois A. Daamen Vincent P. Groot Hanne D. Heerkens Martijn P.W. Intven Hjalmar C. van Santvoort I. Quintus Molenaar |
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Affiliation: | 1. Dept. of Surgery, UMC Utrecht Cancer Center, Utrecht, The Netherlands;2. Dept. of Radiation Oncology, UMC Utrecht Cancer Center, The Netherlands;3. Dept. of Surgery, The John L. Cameron Division of Hepatobiliary and Pancreatic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;4. Dept. of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands |
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Abstract: | BackgroundBiomarker testing can be helpful to monitor disease progression after resection of pancreatic cancer. This systematic review aims to give an overview of the literature on the diagnostic value of serum tumor markers for the detection of recurrent pancreatic cancer during follow-up.MethodsA systematic search was performed to 2 October 2017. All studies reporting on the diagnostic value of postoperatively measured serum biomarkers for the detection of pancreatic cancer recurrence were included. Data on diagnostic accuracy of tumor markers were extracted. Forest plots and pooled values of sensitivity and specificity were calculated.ResultsFour articles described test results of CA 19-9. A pooled sensitivity and specificity of respectively 0.73 (95% CI 0.66–0.80) and 0.83 (95% CI 0.73–0.91) were calculated. One article reported on CEA, showing a sensitivity of 50% and specificity of 65%. No other serum tumor markers were discussed for surveillance purposes in the current literature.ConclusionAlthough testing of serum CA 19-9 has considerable limitations, CA 19-9 remains the most used serum tumor marker for surveillance after surgical resection of pancreatic cancer. Further studies are needed to assess the role of serum tumor marker testing in the detection of recurrent pancreatic cancer and to optimize surveillance strategies. |
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Keywords: | Correspondence: I. Quintus Molenaar, MD, PhD, University Medical Center Utrecht, UMC Cancer Center, PO Box 85500 Internal mail to G 04.228, 3508 GA, Utrecht, The Netherlands. |
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