| 呋喃型倍半萜半乳糖碳苷的合成与药理活性 |
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| 引用本文： | 陈宏明,李树春,王银叶,毛建民,蔡孟深,贾忠建.呋喃型倍半萜半乳糖碳苷的合成与药理活性[J].药学学报,1997,32(10):750-754. |
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| 作者姓名： | 陈宏明 李树春 王银叶 毛建民 蔡孟深 贾忠建 |
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| 作者单位： | 北京医科大学药学院，兰州大学化学系 |
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| 基金项目： | 北京医科大学天然及仿生药物国家重点实验室基金 |
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| 摘 要： | 利用1-O-三氟乙酰基-2,3,4,6-O-四苄基-α-D-吡喃半乳糖分别与7-甲氧基-6-(3-戊烯基)-3,5-二甲基苯并呋喃,7-乙酰氧基-6-(3-戊烯基)-3,5-二甲基苯并呋喃和1,2-Dihydrocacalohastin在Lewis酸存在下反应得到四个新的倍半萜碳苷8,9,10和11,其结构和组成通过元素分析和波谱方法得以鉴定。药理活性实验结果表明该类倍半萜具有钙拮抗作用,而其碳苷类化合物具有钙激动作用。
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| 关 键 词： | 呋喃型倍半萜 碳苷 钙拮抗剂 钙激动剂 |
| 收稿时间： | 1996-11-10 |
THE SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF C GALACTOSIDES OF FURANOSESQUITERPENES |
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| HM Chen,SC Li,YY Wang,JM Mao,MS Cai and ZJ Jia.THE SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF C GALACTOSIDES OF FURANOSESQUITERPENES[J].Acta Pharmaceutica Sinica,1997,32(10):750-754. |
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| Authors: | HM Chen SC Li YY Wang JM Mao MS Cai and ZJ Jia |
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| Institution: | School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083 |
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| Abstract: | Four new C-galactosides were obtained by treatment of 1-O-trifluoroacetly-2, 3, 4, 6-tetra-O-benzly-alpha-D-galactopranose with 7-methoxy-6-(3-pentenyl)-3, 5-dimethylbenzofuran, 7-acetoxy-6-(3-pentenyl)-3, 5-dimethylbenzofuran and 1, 2-dihydrocacalohastin in the presence of Lewis acid. Their structures and compositions were elucidated by elemental analysis and spectroscopic methods. The results of the pharmacological test indicated that the sesquiterpenes are calcium antagonist but their C-galactosides are calcium agonist. |
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| Keywords: | Furanosesquiterpenes C glycosides Calcium antagonists Calcium agonists |
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