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Effects of carbocromene on performance and oxidation of FFA and glucose in isolated atria |
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| Authors: | Dr. K. Süsskand J. R. Sauter Prof. Dr. med. M. Siess |
| Affiliation: | (1) Present address: Pharmakologisches Institut der Universität Tübingen, Wilhelmstr. 56, 7400 Tübingen, F.R.G. |
| Abstract: | Conclusions Carbocromene inhibits only inhypoxic injured atria the palmitate oxidation (–32%), whereas glucose oxidation-rate (+17%) increased at the incubation with the combination of these 2 substrates. In thenormoxic controls, however, the competition of substrates in the biological oxidation after the positive inotropic effect of C. was dependent on the Vmax-and Km-values of the oxidation-rate of each substrate as well as its concentration.If carbocromene inhibits the palmitate oxidation in the stage of its penetration through the cell membrane or in the mitochondrial membrane or by other interference in the hypoxic injured atria cannot be decided yet.Wirkungen von Carbocromen auf Funktion und Oxidation von FFA und Glukose in isolierten Herzvorhöfen Paper, presented at the Erwin Riesch Symposium, Tübingen, April 3–7, 1979 With 1 figure |
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