Antiproliferative effects of abietane diterpenoids isolated from Hyptis martiusii Benth (Labiatae) |
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| Authors: | Costa-Lotufo L V Araújo E C C Lima M A S Moraes M E A Pessoa C Silviera E R Moraes M O |
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| Institution: | Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil. lvcosta@secrel.com.br |
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| Abstract: | Two abietane diterpenes were isolated from a hexane extract of Hyptis martiusii roots and identified as carnasol 11,14-dihidroxy-8,11,13-abietatrien-7-one. These compounds were tested for their antiproliferative effects on tumor cell lines using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide and on the sea urchin egg development. Both compounds displayed cytotoxic activity against tumor cell lines, but only carnasol was able to inhibit the sea urchin egg cleavages. |
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