| 人参二醇组皂甙对失血性休克犬血气和酸硷平衡的影响 |
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| 引用本文： | 刘复兴,王忠山,赵学俭,林桦,赵丹,计国义.人参二醇组皂甙对失血性休克犬血气和酸硷平衡的影响[J].吉林大学学报(医学版),1990(4). |
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| 作者姓名： | 刘复兴 王忠山 赵学俭 林桦 赵丹 计国义 |
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| 作者单位： | 白求恩医科大学病理生理教研室
(刘复兴，王忠山，赵学俭，林桦，赵丹)，白求恩医科大学病理生理教研室(计国义) |
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| 摘 要： | 40只杂种犬随机分为失血性休克人参预治疗组(HSG),失血性休克地塞米松预治疗组(HSD)和失血性休克组(HS)。于放血前1小时HSG组静注人参二醇组皂甙25mg/kg,HSD组肌注地塞米松1 mg/kg,然后颈动脉放血使平均动脉压维持5.33kPa,观察5h。结果表明,人参二醇组皂甙对休克犬PaO_2和O_2CT代偿性增加的程度略大于HSD和HS组,并使血液pH值明显下降的时间迟于HSD和HS组1h,而且pH值下降的程度比HSD和HS组要小。提示人参二醇组皂甙可以缓解代谢性酸中毒发生的程度,其作用显著地优于地塞米松。
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| 关 键 词： | 人参二醇组皂甙 地塞米松 失血性休克 酸硷平衡 血气 |
EFFECT OF PANAXADIOL SAPONINS ON BLOOD GAS AND ACID-BASE BALANCE IN HEMORRHAGICALLY SHOCKED DOGS |
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| Liu Fuxing,Wang Zhongshan,Zhao Xuejian,Lin Hua,Zhao Dan,Ji Guoyi.EFFECT OF PANAXADIOL SAPONINS ON BLOOD GAS AND ACID-BASE BALANCE IN HEMORRHAGICALLY SHOCKED DOGS[J].Journal of Jilin University: Med Ed,1990(4). |
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| Authors: | Liu Fuxing Wang Zhongshan Zhao Xuejian Lin Hua Zhao Dan Ji Guoyi |
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| Institution: | Department of Pathophysiology |
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| Abstract: | Forty mongrel dogs subjected to hemorrhagic hypotension at a mean arterial pressure of 5.33 kPa for 5 hours were divided into 3 groups, with one group pretreated with 25 mg/kg panaxadiol saponins (HSG) i.v., one group pretreated with 1.0 mg/kg dexamethasone (HSD) i.m.and one nonpretreatcd group (HS). The results showed that the degree of increase of PaO2 and O2CT for HSG group was a little higher, and the time of marked pH fall for the same group 1 h later than that in the HSD and HS groups.In addition, the amplitude of decrease of pH in the HSG group was also smaller. |
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| Keywords: | Panaxadiol saponins Dexamethasone Hemorrhagic shock Blood gas Acid-base balance |
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