VPF方案治疗晚期胃癌的临床观察

目的 :探讨鬼臼噻吩甙 (VM 2 6 )、顺铂 (PDD)和氟脲嘧啶 (5 Fu)组成的VPF方案治疗晚期胃癌的近期疗效和毒副反应。方法 :将 1998年 6月至 2 0 0 2年 5月收治的 134例晚期胃癌患者 ,随机分为VPF组和由VP 16、CF及 5 Fu联合的ELF方案组各 6 7例进行化疗 ,二个周期后按WHO标准评定效果。结果 :VPF组有效率为 71 6 % (4 8/6 7) ,ELF组有效率为5 0 7% (34/6 7) ,VPF组有效率高于ELF组 ,两组差异有显著性 (P <0 0 5 )。两组毒副反应主要是轻中度的骨髓抑制、厌食、恶心呕吐及脱发等 ,患者可以耐受。结论 :VPF方案治疗晚期胃癌的近期疗效较好 ,有效率高于ELF方案 ,毒副反应可以耐受 ,值得进一步临床应用观察

Clinical study on the treatment of advanced gastric carcinoma with VPF regimen

Objective:To observe the short-term response and side effect of VPF (VM-26+PDD+5-Fu) on advanced gastric carcinoma.Methods:134 patients with advanced gastric carcinomas from June 1998 to May 2002 were randomized into two groups(each was 67), group one was treated with VPF and group two with ELF(VP-16+CF+5-Fu), responses were evaluated after two therapeutic period.Results:The effective rate for VPF and ELF was 71.6%(48/67) and 50.7(34/67) respectively and the difference between two groups was significant(P<0.05). The main side effects of two groups were depression of bone marrow, nausea, vomiting and alopecia et al and might be mild and tolerable.Conclusion:The short-term therapeutic effect of VPF is better than ELF and their side effects were similar and tolerable. The treatment of advanced gastric carcinoma with VPF is a useful method.