XPD基因多态性与非霍奇金淋巴瘤发病风险

目的探讨核苷酸剪切修复基因(XPD)单核苷酸多态性与非霍奇金淋巴瘤(NHL)发病风险的关系。方法以309例NHL患者和305例健康对照者为研究对象,采用PCR-RFLP技术检测XPDG23591A、A35931C位点的基因多态。结果初步分析XPD G23591A和A35931C基因多态性与总的NHL无显著相关。对NHL亚类分析显示,在滤泡性淋巴瘤(FL)、弥漫性大B细胞淋巴瘤(DLBCL)、其他B细胞NHL和T细胞NHL中,XPD23591位点GA+AA型频率分别为16.3%、18.0%、10.5%、18.4%,对照组为12.5%,OR值分别为1.43、1.58、0.89和1.50,差异无统计学意义(P>0.05);XPD35931位点AC+CC型频率分别为15.2%、15.8%、18.4%、12.5%,对照组为11.5%,OR值分别为1.41、1.48、1.75和1.12,差异亦无统计学意义(P>0.05)。结论山东地区汉族人群XPD G23591A、G23591A位点多态性与非霍奇金淋巴瘤发病无关。

Relationship between XPD Genetic Polymorphism and Risk of Non-Hodgkin's Lymphoma

Objective To explore the relationship between the single nucleotide polymorphisms of XPD(G23591A、A35931C) and individual susceptibility to non-Hodgkin s lymphoma(NHL).Methods XPD G23591A and A35931C genotypes in 309 NHL cases and 305 healthy controls were detected using PCR-restriction fragment length polymorphism assay.Results No significant association between the G23591A,A35931C polymorphisms and the risk of whole NHL was shown.NHL cases were subsetted into four groups: follicular lymphoma group,diffuse large B-cell lymphoma group , T2cell lymphoma group and other B-cell lymphoma group. XPD 23591 GA + AA f requencies were 16. 3 % , 18. 0 % , 10. 5 % and 18. 4 % in each group , while 12. 5 % in cont rols , the ORs were 1. 43 , 1. 58 , 0. 89 and 1. 50 , respectively. But no statistically significant difference was shown ( P > 0. 05) ; XPD 35931AC + CC f requencies were 15. 2 % , 15. 8 % , 18. 4 % and 12. 5 % in each group , while 11. 5 % in cont rols , the ORs were 1. 41 , 1. 48 , 1. 75 and 1. 12 , respectively. But no statistically significant difference was shown ( P > 0. 05) . Con2 clusion 　The XPD genotypes may do not cont ribute to the risk of developing N HL in shandong area populations.