泻必康治疗慢性腹泻的作用机制

目的：探讨泻必康对小鼠免疫作用及肠运动功能的影响。方法：以0.85％氯化钠溶液为对照组，参苓白术散为阳性对照组，采用100％大黄水煎剂灌胃的造模方法，泻必康中药按大、小剂量分别灌胃给药，测定小鼠胸腺和脾脏指数，观察小鼠腹腔巨噬细胞的吞噬功能；采取皮下注射新斯的明的造模方法，泻必康中药按大、小剂量分别灌胃给药，观察泻必康对小鼠小肠推进运动、肠容积以及排便时间和数量的影响。结果：泻必康可显著提高小鼠脾脏指数，明显增强腹腔巨噬细胞的吞噬功能．其吞噬指数及吞噬率均提高，此作用明显优于0．85％氯化钠溶液，与参苓白术散作用相当。泻必康还可显著减缓新斯的明小鼠小肠墨汁的推进速度，对抗肠容积的异常增大，延缓小鼠排便时间，减少排便数量。结论：泻必康具有较强的免疫增强和较好的调整恢复胃肠运动功能作用，这可能是其治疗慢性腹泻的主要作用机制。

Mechanism of Xiebikang in Treating Chronic Diarrhea

jective:To discuss the effect of Xiebikang(XBK) on immune action and motor function of small intestine in mice. Methods: Diarrhea model was made by perfusing the stomach of the mice with 100% Rhubarb-water. Control group was given 0. 85% saline, positive control group given Shenling Baizhu Powder (SBP) and the XBK groups respectively offered with high, midium and low dose of XBK. Thymus and spleen exponents of the mice were estimated and phagocytosis of the celiac macrophages in mice was observed. Then, subcutaneous injection of Neostigmine methylsulfate was taken to make mice models. The effect of XBK on small intestinal motor function, bulk of intestine, time and quantity of defecation was observed. Results: XBK had notable function in raising the spleen exponent of the mice, reinforcing macrophage index and phagocytosis rate, which was more significant than that of 0. 85 % saline and was equivalent to that of SBP. XBK could not only efficiently slow down small intestinal drive velocity of prepared Chinese ink, but also limit abnormal enlargement of intestinal bulk, and postpone defecation time and decrease defecation quantity. Conclusion:XBK has satisfactory functions of reinforcing immune action and adjusting gastrointestinal motor function, which may be the main mechanism in treating chronic diarrhea.