川芎嗪对弥漫性轴索损伤患者凝血功能的影响

目的 探讨川芎嗪对弥漫性轴索损伤（diffuse axonal injury，DAI）患者凝血功能的影响。方法将62例确诊为DAI的患者随机分为常规治疗组（n=30）和川芎嗪治疗组（n=32），治疗前后测定凝血指标（血小板计数、凝血酶原时间、纤维蛋白原及D二聚体等），进行对比分析。结果 DAI患者人院时血小板计数、凝血酶原时间、纤维蛋白原及D二聚体均高于正常。经川芎嗪治疗后，上述指标于1周内逐渐降至正常水平（P〈0．05）；而常规治疗组仍高于正常，与川芎嗪治疗组比较差异有显著性（P〈0．05）。结论 川芎嗪可显著改善弥漫性轴索损伤患者的凝血功能，有利于改善预后。

Effect of Tetramethylpyrazine on Blood Coagulation of Patients with Diffuse Axonal Injury

Objective To explore the effect of tetramethylpyrazine on blood coagulation of patients with diffuse axonal injury （DAI）. Methods 62 patients with DAI were randomly into 2 groups. Group Ⅰ （ n = 30）received conventional therapy and group Ⅱ （n = 32 ） received conventional therapy plus Tetrameth- ylpyrazine treatment. Indices of blood coagulation such as platelets count, prothrombin time, fibrinogen and D-dimer were measured before and after therapy and the indices were compared. Results The platelets count, prothrombin time, the level of fibrinogen and D-dimer were significantly increased and were decreased to normal level in 1 week after Tetramethylpyrazine infusion intravenously （ P 〈 0.05 ）. The blood coagulation indices of group Ⅰ were significantly higher than that in group Ⅱ. Conclusion Tetramethylpyrazine can improve the function of blood coagulation and then improve the prognosis of patients with diffuse axonal injury.