| T细胞受体二次重排的基础与临床 |
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| 引用本文： | 申健,罗微,马骊.T细胞受体二次重排的基础与临床[J].国际免疫学杂志,2001,32(1):273-277. |
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| 作者姓名： | 申健 罗微 马骊 |
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| 作者单位： | 南方医科大学生物技术学院分子免疫学研究所,广州,510515; |
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| 基金项目： | 教育部新世纪优秀人才支持计划国家自然科学基金广东省自然科学基金 |
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| 摘 要： | 重组激活基因(RAG)能被诱导再次表达引起T细胞受体(TCR)二次重排,进而在TCR库的形成和丰富中发挥重要作用.二次重排发生于外周者称为受体修正(receptor revision),发生于中枢者则称为受体编辑(receptor editing).研究发现,TCR编辑/修正可存在于肿瘤、感染、移植及自身免疫等疾病状态下,且与疾病发生有密切联系.目前,国内外已有学者利用动物模型或人类细胞研究TCR编辑/修正,并对其机制进行了初步探索.
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| 关 键 词： | T细胞受体 二次重排 受体编辑 受体修正 |
The experimental and clinical study on TCR secondary rearrangements |
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| SHEN Jian,LUO Wei,MA Li.The experimental and clinical study on TCR secondary rearrangements[J].International Journal of Immunology,2001,32(1):273-277. |
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| Authors: | SHEN Jian LUO Wei MA Li |
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| Abstract: | It is found that T cell receptor (TCR) may perform secondary rearrangement under the condition of indued recombination activating genes (RAG) re-expression, thus shaping and enriching the T cell repertoire. Peripheral and central changes of TCR are called receptor revision and receptor editing, respectively, and they may occur and play a role in neoplasm, infection, transplantation and autoimmune diseases. The naechanisms of TCR editing and revision are explored with both animal models and human cells. The progress in the research of TCR editing and revision is reviewed. |
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| Keywords: | TCRRAGSecondary rearrangementReceptor editingReceptor revision |
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