Calcium/calmodulin signaling elicits release of cytochrome c during 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptosis in the human lymphoblastic T-cell line,L-MAT |
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| Authors: | Daisuke Kobayashi Sohel Ahmed Masato Ishida Shuya Kasai Hideaki Kikuchi |
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| Affiliation: | 1. Science of Bioresources, United Graduate School of Agricultural Sciences, Iwate University, Morioka 020-8551, Japan;2. Division of Cell Technology, Department of Biochemistry and Biotechnology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki 036-8561, Japan;3. Department of Molecular Genetics, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan |
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| Abstract: | We have reported previously that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces apoptosis in the human lymphoblastic T-cell line L-MAT, although these cells do not express the aromatic hydrocarbon receptor (AhR). The AhR-dependent pathway for the induction of immunotoxicity by TCDD has been studied extensively, but the AhR-independent pathway is not understood. Several studies have reported that TCDD elevates the concentration of free intracellular calcium ([Ca2+]i) in various types of cells. However, the precise mechanism of the increase in [Ca2+]i that occurs during apoptosis induced by TCDD has not been elucidated. |
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| Keywords: | Calcium Calmodulin Dioxin Apoptosis Lymphoblastic T-cell line |
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