| 小儿热感宁注射液在兔体内的药代动力学研究 |
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| 引用本文： | 黄雪梅,路玫,潘洪平,荆树汉.小儿热感宁注射液在兔体内的药代动力学研究[J].中国药房,2001,12(10):584-585. |
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| 作者姓名： | 黄雪梅 路玫 潘洪平 荆树汉 |
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| 作者单位： | 广西壮族自治区人民医院药剂科, |
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| 基金项目： | 广西壮族自治区卫生厅科研课题(Z9706) |
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| 摘 要： | 目的 :研究小儿热感宁注射液在家兔体内的药代动力学特征。方法 :采用高效液相色谱法测定小儿热感宁注射液中主要成分葛根素在兔血浆中的浓度 ,用3p87程序计算药代动力学参数。结果 :小儿热感宁注射液在兔体内的药代动力学过程符合开放二室模型 ,主要药代动力学参数为T1/2α=5 25min ,T1/2β=36 04min ,K10=0 042min ,K12=0 063min ,K21=0 093min ,AUC=2561 49μg/(ml·min) ,CL=4 6ml/(min·kg)。结论 :该研究可为小儿热感宁注射液的临床应用提供一定科学依据
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| 关 键 词： | 小儿热感宁注射液 葛根素 药代动力学 高效液相色谱法 |
| 文章编号： | 1001-0408(2001)10-0584-02 |
| 修稿时间： | 2001年3月12日 |
Pharmacokinetics of Xiaoer Reganning Injection in Rabbits |
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| HUANG Xuemei,LU Mei,PAN Hongping,JING Shuhan.Pharmacokinetics of Xiaoer Reganning Injection in Rabbits[J].China Pharmacy,2001,12(10):584-585. |
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| Authors: | HUANG Xuemei LU Mei PAN Hongping JING Shuhan |
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| Abstract: | OBJECTIVE:The pharmacokinetics of Xiaoer Reganning injection was determined in rabbits METHODS:The concentrations of puerarin in Xiaoer Reganning injection in plasma were determined by HPLC The analytical column was No _va-pak C18 (4μm,150mm×3 9mm ID) The mobile phase consisted of methol-water(20∶80) The detecting wavelength was 250nm The 3p87 program was used to calculate the pharmacokinetic parameters RESULTS:The in vivo pharmacokinetic course of puerarin in Xiaoer Reganning injection could be described as an open two-compartment model Its main pharmacokinetic parameters were as follows:T1/2(α)=5 25min,T1/2(β)=36 04min,K10=0 042min,K12=0 063min,K21=0 093min,AUC=2 561 49μg/(ml·min),CL=4 6ml/(min·kg) CONCLUSION:This study will provide a scientific basis for clinical use of Xiaoer Reganning injection |
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| Keywords: | Xiaoer Reganning injection puerarin pharmacokinetics HPLC |
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