Aggravation of non-steroidal anti-inflammatory drug-induced hepatitis and acute renal failure by slimming drug containing anthraquinones. |
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| Authors: | Fu Keung Li Chi-Kong Lai Wing Tat Poon Albert Yan Wo Chan Kwok Wah Chan Kai Chung Tse Tak Mao Chan Kar Neng Lai |
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| Affiliation: | Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong. fkli@hku.hk |
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| Abstract: | | Introduction | The renal toxicities of non-steroid anti-inflammatory drugs(NSAIDs) have been well reported [1] and the mechanism of injuryis thought to be mediated by haemodynamic perturbation whichresults in functional renal ischaemia. The typical histologicalabnormality is acute tubular necrosis, which is usually reversible. Anthraquinone and its derivatives are frequently found in slimmingagents and have been valued for their cathartic and presumeddetoxifying action. Diarrhoea, vomiting and abdominal discomfortare common side-effects, and in severe cases, may result indehydration. Renal and liver complications resulting from the
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| Keywords: | acute renal failure anthraquinone hepatitis non-steroidal anti-inflammatory drugs slimming |
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