| 谷胱甘肽S转移酶M1基因缺失与乳腺癌易患性的关系 |
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| 引用本文： | 王小飞,钱勣虎,王惠民,吴志美. 谷胱甘肽S转移酶M1基因缺失与乳腺癌易患性的关系[J]. 南通医学院学报, 2002, 22(1): 11-12 |
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| 作者姓名： | 王小飞 钱勣虎 王惠民 吴志美 |
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| 作者单位： | 1. 南通医学院附属医院检验科,南通,226001
2. 南通医学院免疫学教研室 |
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| 摘 要： | 目的 :探讨谷胱甘肽 S转移酶 ( glutathione S- transferase GST)基因缺失与乳腺癌易患性的关系。方法 :应用多重聚合酶链反应 ( polym erase chain reaction,多重 PCR)方法对 4 2例乳腺癌患者和 10 8例健康人外周血细胞进行 GSTM1 基因检测。结果 :乳腺癌组 GSTM1 基因缺失率为 5 7.1% ,对照组为 4 8.1% ,两组之间差异无显著性(χ2 =0 .98,P>0 .0 5 )。结论 :GSTM1 基因缺失与乳腺癌的发生无显著性关系
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| 关 键 词： | 谷胱甘肽S转移酶 乳腺癌 基因缺失 GSTM基因 |
| 文章编号： | 1000-2057(2002)01-0011-02 |
| 修稿时间： | 2001-05-10 |
RELATIONSHIP BETWEEN GSTM1 GENE DELETION AND SUSCEPTIBILITY TO BREAST CANCER |
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| WANG Xiaofei,QIAN Jihu,WANG Huimin,et al. RELATIONSHIP BETWEEN GSTM1 GENE DELETION AND SUSCEPTIBILITY TO BREAST CANCER[J]. ACTA Academiae Medicinae Nantong, 2002, 22(1): 11-12 |
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| Authors: | WANG Xiaofei QIAN Jihu WANG Huimin et al |
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| Affiliation: | WANG Xiaofei,1QIAN Jihu,WANG Huimin,et al |
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| Abstract: | Objective:To study the relationship between the glutathiones-transferase gene deletion and susceptibility to breast cancer. Methods:Blood cells of total of 42 cases with breast cancer and 108 controls were analyzed with PCR. Result:The GSTM 1 gene deletion rate in breast cancer group was 57.1% and that in control was 48.1%. There is not significant difference between them . Conclusion: GSTM 1 gene deletion is not related to breast cancer formation. |
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| Keywords: | Glutathione transferase Gene Breast cancer |
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