| 氧自由基动态变化与胆红素结石成石的实验研究 |
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| 引用本文： | 刘鹏飞,肖路加,陈继镛.氧自由基动态变化与胆红素结石成石的实验研究[J].四川大学学报(医学版),1994(4). |
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| 作者姓名： | 刘鹏飞 肖路加 陈继镛 |
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| 作者单位： | 四川大学分析测试中心，第二军医大学长海医院肝胆外科 |
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| 摘 要： | 用胆红素结石（ｐｓ）兔模型进行实验，设单纯胆道梗阻（ＢＯ）组、梗阻和大肠杆茵感染（ＢＯＩ）组及空白对照组，观察肝组织及胆汁氧自由基（ＯＦＲ）变化情况及对ＰＳ的影响。实验结果：肝组织部分ＯＦＲ、前列腺素Ｅ＿２（ＲＧＥ＿２）及ＰＳ的动态变化趋势相似，三者呈正相关；ＢＯＩ组的上述指标均较ＢＯ组为高。提示ＯＦＲ可能促使ＰＧＥ＿２合成，后者致糖蛋白分泌而参与ＰＳ的形成；大肠杆菌感染可能在梗阻的基础上增多ＯＦＲ的生成而增加了Ｐｓ的形成。
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| 关 键 词： | 氧自由基，前列腺素E＿2，胆红素结石，兔 |
Alterations of Oxygen Free Radicals in Rabbit Models and Its Relation to Formation of Pigment Gallstones |
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| Liu Penqfei, Xiao Lujia, Chen Jiyong l.Alterations of Oxygen Free Radicals in Rabbit Models and Its Relation to Formation of Pigment Gallstones[J].Journal of West China University of Medical Sciences,1994(4). |
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| Authors: | Liu Penqfei Xiao Lujia Chen Jiyong l |
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| Abstract: | The experimental rabbits were dividedinto three groups. In the first group the common bileducts were loosely ligated and contaminated by E. coli(BOI );in the second group the commion bile ductswere only loosely ligated(BO);and the third groupwas the control group (Con ).Alterations of oxygenfree radicals were studied in all these models.The re-sult showed that alterations of the partial hepatic oxy-gen free radicals (OFR ), the hepatic prostaglandin E_2(PGE_2 )and the pigment gallstones were similar. Therewas a positive correlation among them(P<0. 05 ).Ingroup BOI these indexes were higher than in groupBO. It is suggested that oxygen free radicals are possi-bly responsible for the formation of pigment gallstonesthrough the pathway from oxygen free radicals to pro-mote the production of prostaglandin E_2,glycoproteinand pigment gallstones at last E. coli may aggravatethe formation of pigment gallstones by increasingliepatic oxygen free radicals. |
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| Keywords: | Oxygen free radicals Prostaglandin E_2 Pigment gallstones Rabbit |
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