Effect of insulin on the production and action of interleukin 1 |
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Authors: | Feng Zuo-hua Luo Yi Wang Ru-duan Chen Zhao-cong |
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Institution: | (1) Department of Medical Molecular Biology, Tongji Medical University, Wuhan |
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Abstract: | Summary The effect of insulin on the production and action of interleukin 1 (IL-1) was investigated in this study. After being treated
with nylon wool to remove adherent cells, the thymocytes showed only a weak response to Con A in the abscence of exogenous
IL-1, and this response could not be influenced by insulin. Insulin was able to significantly enhance the response of thymocytes
to Con A if the thymocytes were not pre-treated with nylon wool, and it was able to significantly enhance the response of
the thymocytes treated with nylon wool to Con A in the presence of exogenous IL-1. It has been demonstrated that insulin could
augment the production of IL-1 by macrophages stimulated by LPS. These results suggest that the regulating action of insulin
on T cell activation is associated with macrophages or IL-1, and insulin might exert a regulating role on other reactions
mediated by IL-1. Furthermore, our results demonstrated that the action of active insulin could be weakened by the presence
of inactive insulin. |
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Keywords: | insulin interleukin 1 thymocyte |
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