IMMUNOLOGICAL STUDIES IN TWO CHILDREN WITH RECURRENT PAROTITIS |
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| Authors: | B. FRIIS,F. KARUP PEDERSEN,M. SCHIØ DT,A. WIIK,L. HØ J,V. ANDERSEN |
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| Affiliation: | University Clinic of Infectious Diseases;The University Clinic of Paediatrics. Department G.;The Department of Oral Medicine and Oral Surgery and the;The Laboratory of Medical Immunology, Rigshospitalet, Copenhagen, Denmark |
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| Abstract: | ABSTRACT. In two children with recurrent parotitis, labial salivary gland biopsies showed chronic sialoadenitis. Immunofluorescence studies disclosed deposits of immunoglobulins and complement in juxta-acinar small vessels. Case 1 had gluten enteropathy, IgA deficiency and high titres of antinuclear antibodies (ANA), and in vivo fixation of ANA to nuclei of different cells in lip, skin and jejunum was present. Case 2 showed deposition of IgM in the dermo-epidermal junction of the skin. These findings suggest that autoimmune reactivity and immune complexes may play a role in the pathogenesis of this disorder. |
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| Keywords: | Recurrent parotitis salivary gland/immunofluorescence immune complex disease autoimmunity IgA deficiency coeliac disease |
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