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CUTANEOUS VASCULITIS DUE TO CYCLOPHOSPHAMIDE THERAPY FOR CHRONIC LYMPHOCYTIC LEUKEMIA |
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| Authors: | R. MALCOLM GREEN GRAHAM J. SCHAPEL ROBERT E. SAGE |
| Affiliation: | Registrar in Clinical Haematology and Oncology, The Queen Elizabeth Hospital, Woodville, SA;Senior Staff Specialist Physician, Clinical Pharmacology/Neurology, The Queen Elizabeth Hospital, Woodville, SA;Senior Director, Department of Clinical Haematology, The Queen Elizabeth Hospital, Woodville, SA |
| Abstract: | A 55-year-old male with chronic lymphocytic leukemia developed a skin eruption after receiving oral cyclophosphamide. Subsequent rechallenge with parenteral cyclophosphamide led to recurrence of the skin lesions, which on biopsy were shown to be vasculitic in nature. (Aust NZ J Med 1989; 19: 55–57.) |
| Keywords: | Adverse drug reaction cyclophosphamide chronic lymphocytic leukemia vasculitis immunological mechanism |