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白细胞介素-6基因多态性与冠心病的相关性研究及其对血脂的影响
引用本文:韦叶生,蓝艳,刘运广,唐任光,蓝景生. 白细胞介素-6基因多态性与冠心病的相关性研究及其对血脂的影响[J]. 中国危重病急救医学, 2006, 18(4): 233-236
作者姓名:韦叶生  蓝艳  刘运广  唐任光  蓝景生
作者单位:1. 533000,广西,百色,右江民族医学院附属医院检验中心
2. 533000,广西,百色,右江民族医学院附属医院心内科
基金项目:广西壮族自治区医药卫生科研项目(Z2004037)
摘    要:目的 探讨白细胞介素6(IL-6) 基因启动子区基因-572位点和-634位点多态性与冠心病的关系,及其对血脂、脂蛋白、载脂蛋白水平的影响.方法 采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测165例冠心病(冠心病组)患者和170名健康人(对照组) 的IL-6基因型;按常规方法测定血脂、脂蛋白、载脂蛋白水平.结果 冠心病组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均明显高于对照组(P均〈0.05);IL-6基因-634位点多态性在冠心病组和对照组的分布差异无显著性(P〉0.05),而IL-6基因-572位点多态性在两组人群中的分布差异存在显著性(P〈0.05);等位基因频率的相对风险分析发现,G等位基因携带者患冠心病的风险是C等位基因的1.652倍[相对比值比(OR)=1.652,95%可信区间(CI):1.137~2.401],携带G等位基因的冠心病个体血清TC水平显著高于不携带者(P〈0.05).结论 IL-6基因-572位点多态性与冠心病的发病具有相关性,其中G等位基因是冠心病重要的遗传标记;IL-6基因-572位点多态性可能通过影响血脂水平而影响冠心病的发生.

关 键 词:白细胞介素-6 冠心病 基因多态性 血脂
收稿时间:2005-08-02
修稿时间:2006-03-16

Relationship between interleukin-6 gene polymorphism and coronary heart disease and its effect on plasma lipid levels
WEI Ye-sheng,LAN Yan,LIU Yun-guang,TANG Ren-guang,LAN Jing-sheng. Relationship between interleukin-6 gene polymorphism and coronary heart disease and its effect on plasma lipid levels[J]. Chinese critical care medicine, 2006, 18(4): 233-236
Authors:WEI Ye-sheng  LAN Yan  LIU Yun-guang  TANG Ren-guang  LAN Jing-sheng
Affiliation:Department of Clinical Laboratory Center, The Affiliated Hospital to Youjiang Nationality Medical College, Youjiang 533000, Guangxi, China. weiyesheng@yahoo.com.cn
Abstract:OBJECTIVE: To study the relationship between interleukin-6 (IL-6) gene promoter-572 C/G and -634 C/G polymorphism and coronary heart disease (CHD) and the influence of IL-6 gene polymorphism on plasma lipid and lipoprotein levels. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for the detection of IL-6 genotype in 165 patients with CHD and 170 healthy persons. The plasma lipid and lipoprotein levels were measured by routine method. RESULTS: Plasma total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) of the patients with CHD were significantly higher than those of the controls (all P<0.05). The distributions of IL-6 gene -634 C/G polymorphism were not different between CHD group and control group (P>0.05), but the IL-6 gene-572 C/G polymorphism was significantly different between them (P<0.05). The relative risk of CHD of C allele was 1.652 times to the G allele [odds ratio (OR)=1.652, 95% confidence interval (CI): 1.137-2.401]. The level of plasma lipid in G allele carriers was significantly higher than non-carriers (P<0.05). CONCLUSION: IL-6 gene -572 C/G polymorphism is associated with CHD, and G allele is an important genetic marker. IL-6 gene polymorphism may affect CHD through elevation of plasma lipid and lipoprotein levels.
Keywords:interleukin - 6   coronary heart disease   gene polymorphism   plasma lipid
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