环维黄杨星D对大鼠心脏功能及血压的作用

目的观察环维黄杨星D(CVB-D)对正常大鼠在体心脏功能和血压的调节作用。方法雄性SD大鼠灌胃给予CVB-D 3.35 mg·kg~(-1)·d~(-1),分别于给药2,4和6周后,用血流动力学方法观察大鼠的收缩压、舒张压、左室收缩压(LVSP)、左室舒张末压(LVEDP)、左室压力最大变化速率(±dp/dt_(max))以及心率。结果与对照组相比,灌胃给予CVB-D 6周后,大鼠LVSP增高,收缩压降低。而各时间点给药组LVEDP、±dp/dt_(max)、舒张压及心率均未发生明显改变。结论CVB-D对在体大鼠有一定的增强心脏功能和降低主动脉压力效应,同时不会引起心动过速。

Effect of cyclovirobuxine-D on heart function and blood pressure of rats in vivo

AIM To explore effects of cyclovirobuxine-D (CVB-D) on heart function and blood pressure of rats in vivo . METHODS CVB-D 3.35 mg·kg^-1·d^-1 was given (ig) to male SD rats for 2, 4 and 6 weeks, then proceeded in vivo hemodynamic measurements through right carotid artery. Left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), maximal rate of rise and decline of left ventricular pressure (±dp/dt_max), systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were detected by the Medlab 6 system. RESULTS No significant differences were observed in 2-week and 4-week groups. LVSP elevated notably in 6-week CVB-D group，while SBP decreased. LVEDP, ±dp/dt_max, DBP and HR stayed stable in two groups. CONCLUSION CVB-D can improve heart function and lower blood pressure, while not quickening the heart rate synchronously.