| 具有拮抗谷氨酸神经毒作用的中药集群筛选 |
| |
| 引用本文： | 陈立娜,都述虎. 具有拮抗谷氨酸神经毒作用的中药集群筛选[J]. 现代中药研究与实践, 2007, 21(6): 23-25 |
| |
| 作者姓名： | 陈立娜 都述虎 |
| |
| 作者单位： | 南京医科大学,江苏,南京,210029;南京医科大学,江苏,南京,210029 |
| |
| 基金项目： | 南京医科大学科技发展基金(NY04020) |
| |
| 摘 要： | 目的从治疗缺血性脑中风中药中筛选具有拮抗谷氨酸神经毒作用的活性中药。方法以PC12细胞为对象,用200 mmol.L-1谷氨酸(G lu)造成细胞损伤模型,MTT法检测细胞活力。结果毛冬青、苏木、茜草、虎杖4种中药可明显提高谷氨酸诱导的PCI2细胞还原M IT的能力(P<0.05)。结论毛冬青、苏木、茜草、虎杖4种中药对谷氨酸所致的细胞损伤具有较好的保护作用。
|
| 关 键 词： | 活性筛选 PC12细胞 谷氨酸 中药 |
| 文章编号： | 1673-6427（2007）06-0023-03 |
| 收稿时间： | 2007-08-22 |
| 修稿时间： | 2007-08-22 |
Protective Effect of Traditional Chinese Drug of Screening on Glu Induced Neurotoxicity in Cultured PC12 Cell |
| |
| CHEN Li-na,DU Shu-hu. Protective Effect of Traditional Chinese Drug of Screening on Glu Induced Neurotoxicity in Cultured PC12 Cell[J]. Research and Practice on Chinese Medicines, 2007, 21(6): 23-25 |
| |
| Authors: | CHEN Li-na DU Shu-hu |
| |
| Abstract: | Objective Screening of antagonistic action on neurotoxicity induced by glutamate(Glu) from Traditional Chinese Medicines in treatment of cerebrovascular ischemic diseases.Methods Cultured PC12 cells were treated with 20 0mmol·L-1 Glu,the cell viability was detected with MTT method.Results Radix ilecis pubescens,Lignum sappan,Indian madder root and Giant knotweed rhizome of 4 kinds Chinese Medicine had significantly increased the ability of reducing MTT by Glu-induced PC12 neuronal cells.Conclusion Screening of 4 Chinese Medicine has protective effects on Glu-induced injury in neuronal PC12 cells. |
| |
| Keywords: | activity screening PC12 cell Glu Chinese Medicine |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
