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Aetiology of acute sporadic non-A,non-B viral hepatitis in India
Authors:V. A. Arankalle  L. P. Chobe  J. Jha  M. S. Chadha  K. Banerjee  M. O. Favorov  T. Kalinina  H. Fields
Abstract:Non-A, non-B (NANB) hepatitis viruses are now classified as hepatitis E (enterically transmitted) and hepatitis C (parenterally transmitted). India experiences a large number of epidemics of the enteric disease every year. In addition, about 70% of the sporadic cases among adults are also due to NANB hepatitis. With the availability of an immunoblot assay for the detection of anti-HEVIgM and the polymerase chain reaction (PCR) for the detection of HCV-RNA, serum samples from epidemic and sporadic NANB patients were screened for these markers. We found that a large number of cases from the epidemics were HEV, though a few remained undiagnosed, while of the sporadic cases only a few could be diagnosed as HCV or HEV; a large proportion remained undiagnosed. © 1993 Wiley-Liss, Inc.
Keywords:immunoblot  PCR  anti-HEVIgM  HCV-RNA
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