Rapid MR imaging of a vascular challenge to focal ischemia in cat brain |
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Authors: | Alexander J. De Crespigny Michael F. Wendland Nikita Derugin Zinaida S. Vexler Michael E. Moseley |
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Abstract: | Deoxygenated blood was effectively used as a magnetic resonance (MR) susceptibility contrast agent to distinguish perfused and nonperfused (ischemic) regions in a focal ischemia model in cat brain at 2 T. Modulation of cerebral blood oxygenation levels in response to apnea was followed in real time with T2*-weighted (gradient-recalled) echo-planar MR imaging. Signal loss in the T2*-weighted images occurred only in perfused tissues as blood became globally deoxygenated. These data complemented information from diffusion-weighted and contrast agent bolus–-tracking images. In addition, observation of the signal recovery behavior on reventilation in both normal and ischemic brain offered potentially useful information about the state of the cerebral autoregulatory mechanism. |
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Keywords: | Brain, ischemia, 10.769 Brain, perfusion, 10.121416 Brain. MR, 10.121416 Functional studies Oxygen Vascular studies |
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