| NLRP3炎性小体与慢性疼痛 |
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| 引用本文： | 赵庆祥,吴小娟,高勇,林峰,商青青. NLRP3炎性小体与慢性疼痛[J]. 临床麻醉学杂志, 2021, 37(7): 773-776 |
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| 作者姓名： | 赵庆祥 吴小娟 高勇 林峰 商青青 |
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| 作者单位： | 256603 山东省滨州市,滨州医学院附属医院疼痛科;256603 山东省滨州市,滨州医学院附属医院数据统计中心;256603 山东省滨州市,滨州医学院附属医院麻醉科 |
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| 摘 要： | 慢性疼痛是一类机制复杂的疾病,神经炎症被广泛认为是一种重要的促进机制.而NLRP3炎性小体是模式识别受体激活后形成的一种多蛋白复合体,在接收到外源性和内源性信号后,能促进炎性细胞因子的产生,继而引发神经炎症.众多证据表明,NLRP3炎性小体介导的神经炎症在慢性疼痛的发生发展中起着重要作用,靶向NLRP3可能是一种新颖而...
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| 关 键 词： | NLRP3炎性小体 慢性疼痛 白细胞介素-1β 白细胞介素-18 |
NLRP3 inflammasomes and chronic pain |
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| ZHAO Qingxiang,WU Xiaojuan,GAO Yong,LIN Feng,SHANG Qingqing. NLRP3 inflammasomes and chronic pain[J]. The Journal of Clinical Anesthesiology, 2021, 37(7): 773-776 |
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| Authors: | ZHAO Qingxiang WU Xiaojuan GAO Yong LIN Feng SHANG Qingqing |
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| Affiliation: | Department of Pain Management, Binzhou Medical University Hospital, Binzhou 256603, China |
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| Abstract: | Chronic pain is a series of disease with complex mechanism, and neuroinflammation was widely considered as a vital mechanism. NLRP3 inflammasomes are multiprotein complex formed from the activation of pattern recognition receptors. After receiving exogenous and endogenous noxious signals, they could facilitate the production of inflammatory cytokines and trigger neuroinflammation. the emerging researches have displayed that NLRP3 inflammasomes mediated neuroinflammation played a critical role in the development and formation of chronic pain, so targeting NLRP3 inflammasomes may be a novel and effective strategy for the treatment of chronic pain, which has been a hotspot in recent years. This review presents a narrative overview of the current understanding of the role of NLRP3 inflammasomes in chronic pain. |
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| Keywords: | NLRP3 inflammasomes Chronic pain Interleukin-1beta Interleukin-18 |
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