Epstein-barr virus and gastric cancer: Data and unanswered questions |
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| Authors: | Lorenzo Leoncini,Carla Vindigni,Tiziana Megha,Ilaria Funt ,Lorenzo Pacenti,Mariantonietta Musar ,Piero Tosi,Alessandra Renieri,Marco Seri,Joannes Anagnostopoulos |
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| Affiliation: | Lorenzo Leoncini,Carla Vindigni,Tiziana Megha,Ilaria Funtò,Lorenzo Pacenti,Mariantonietta Musarò,Piero Tosi,Alessandra Renieri,Marco Seri,Joannes Anagnostopoulos |
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| Abstract: | Sixty-five unselected cases of gastric cancer have been analysed for EBV DNA by polymerase chain reaction, in situ hybridization and immunohistochemistry for CD21 antigen expression. Four cases were found EBV-positive by PCR, while ISH yielded positive results in 3 of these cases, demonstrating EBV in the nuclei of cancerous cells. CD21 antigen was expressed in cancerous cells in all 3 ISH-positive cases. All the EBV-positive cancers of the present series were poorly to moderately differentiated adenocarcinomas with prominent lymphoid infiltration. These results are discussed also on the basis of the literature. |
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