Simultaneous temperature and regional blood volume measurements in human muscle using an MRI fast diffusion technique |
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Authors: | Daniel Morvan Anne Leroy-Willig Agns Malgouyres Charles A Cuenod Philippe Jehenson Andr Syrota |
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Institution: | Daniel Morvan,Anne Leroy-Willig,Agnès Malgouyres,Charles A. Cuenod,Philippe Jehenson,André Syrota |
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Abstract: | The thermal dependence of the translational diffusion coefficient and of the regional blood volume was investigated in vivo by using a special MR pulsed gradient technique with reduced sensitivity to bulk tissue motion. Measurements were done at 0.5 T, using a small gradient insert. The diffusion coefficient of muscle water was calibrated against thermocouple-measured temperature in vitro, both with the muscle fibers parallel and perpendicular to the diffusion gradient. The maximum muscle temperature variation obtained by percutaneous conduction was ?8.8 ± 1.6°C under cooling and +3.7 ± 1.6°C under heating, from basal state. Simultaneously the fractional regional blood volume decreased by a factor of 3.5 under cooling and increased by a factor of 2.7 under heating. Due to the interdependence of microcirculation and tissue temperature, this technique may be used to follow heat production or deposition in living tissue (muscle exercise, electromagnetic irradiation, etc.). |
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Keywords: | MRI molecular diffusion temperature blood volume |
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