| 药物诱导的粒细胞缺乏症研究进展 |
| |
| 引用本文： | 卢翠翠, 赵文博, 沈姗, 张文, 沈承武. 药物诱导的粒细胞缺乏症研究进展[J]. 中国现代应用药学, 2021, 38(12): 1524-1528. DOI: 10.13748/j.cnki.issn1007-7693.2021.12.021 |
| |
| 作者姓名： | 卢翠翠 赵文博 沈姗 张文 沈承武 |
| |
| 作者单位： | 1.1. 山东第一医科大学附属省立医院, 药学部, 济南 250021 |
| |
| 基金项目： | 国家自然科学基金项目（81800161） |
| |
| 摘 要： | 粒细胞缺乏症是一种罕见且潜在威胁生命的疾病,70％～90％的粒细胞缺乏症是由药物引起的.药物诱导的粒细胞缺乏症(drug-induced agranulocytosis,DIAG)的特征是循环粒细胞显著减少或绝对缺乏,中性粒细胞绝对值＜0.5×109·L-1.DIAG几乎涉及所有品类的药品,其中风险较高的药物包括抗甲状...
|
| 关 键 词： | 粒细胞缺乏症 中性粒细胞 药物不良反应 |
| 收稿时间： | 2020-08-05 |
Research Progress in Drug-induced Agranulocytosis |
| |
| LU Cuicui, ZHAO Wenbo, SHEN Shan, ZHANG Wen, SHEN Chengwu. Research Progress in Drug-induced Agranulocytosis[J]. Chinese Journal of Modern Applied Pharmacy, 2021, 38(12): 1524-1528. DOI: 10.13748/j.cnki.issn1007-7693.2021.12.021 |
| |
| Authors: | LU Cuicui ZHAO Wenbo SHEN Shan ZHANG Wen SHEN Chengwu |
| |
| Affiliation: | 1.1. Shandong Provincial Hospital Affiliated to Shandong First Medical University, Department of Pharmacy, Jinan 250021, China |
| |
| Abstract: | Agranulocytosis is a rare and potentially life-threatening disease, which is attributable to drugs in about 70%-90% of cases. Drug-induced agranulocytosis(DIAG) is characterized by a remarkable decrease or an absolute lack of circulating granulocytes, with a neutrophil count of<0.5×109·L-1 in blood circulation. Almost all classes of drugs have been implicated with DIAG, but the high risk is only associated with several kind of drugs, such as antithyroid drugs, psychotropic agents and antibiotics. DIAG is an adverse reaction to the drug due to individual-specific susceptibility, and is usually not associated with the administered dose. The pathological mechanism of DIAG is related to direct cytotoxicity, immune reaction and genetic susceptibility. Immediate discontinuation of the suspected drug, initiation of broad-spectrum antibiotics and consideration of the use of haematopoietic cell growth factors in high-risk patients are critical to reducing the mortality of DIAG. |
| |
| Keywords: | agranulocytosis|neutrophil|drug adverse reaction |
|
| 点击此处可从《中国现代应用药学》浏览原始摘要信息 |
|
点击此处可从《中国现代应用药学》下载全文 |
|
