沈阳地区重型肝炎血清中庚型肝炎病毒核酸的检测

为调查重型肝炎的庚型肝炎病毒 ( HGV)的感染状况。我们应用逆转录 -巢式聚合酶链反应 ( Rt- nested PCR)检测了 4 9例重型肝炎患者血清中的庚型肝炎病毒核酸 ( HGV RNA)。结果显示 :8例 HGV RNA阳性 ( 16.3% ) ,其中 6例死亡 ( 75% ) ;8例 HGV感染的重型肝炎患者中 7例重叠感染乙型肝炎病毒 ( HBV)或丙型肝炎病毒 ( HCV) ,1例为单纯 HGV感染。提示 :HGV与其它肝炎病毒重叠感染及单纯 HGV感染均可引起重型肝炎 ;而且其临床表现较重 ,病死率高。

Detection of HGV RNA in Sera from Patients with Fulminant Hepatitis in Shenyang

HGV RNA was detected by Rt- nested PCR in sera from4 9patients with fulminant hepatitis.The results showed:a) HGV RNA positive rate was16. 3% ( 8/ 4 9) in patients with fulminant hepatitis including4 subjects with HBV coinfection,1subject with HCV coinfection,2 subjects with HBV and HCV coinfection and1subject with HGV infection alone.b) mortality in patients with fulminant hepatitis with HGV infection was75% ( 6/ 8) ,suggesting that:a) both infection with HGV alone and super infections of other types of hepatitis virus can result in fulminant hepatitis. b) clinical manifestaitions of fulminant hepatitis with HGV infection may appear to be more severe and with higher mortality.