Canine distemper virus does not infect oligodendrocytes in vitro |
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| Authors: | M Vandevelde A Zurbriggen M Dumas D Palmer |
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| Institution: | 1. Institute of Comparative Neurology, University of Berne, Berne Switzerland;2. Department of Neurology, University of Berne, Berne Switzerland;3. Institute of Veterinary Pathology, University of Zurich, Zurich Switzerland |
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| Abstract: | Dissociated canine brain cell cultures were infected with virulent canine distemper virus (CDV). Double immunofluorescent labelling was done to simultaneously demonstrate viral antigen and specific glial cell markers. Virus containing oligodendrocytes were not found at any stage of the infection. A certain proportion of the infected cells were shown to be astrocytes. It was concluded that CDV has no obvious tropism for oligodendrocytes which could explain the mechanism of demyelination in distemper in vivo. |
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| Keywords: | Astrocytes Canine distemper virus Oligodendrocytes |
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