甘草酸二铵用于抗精神病药物所致肝损害的疗效分析

目的:观察甘草酸二铵治疗抗精神病药物所致肝损害的疗效和安全性。方法:对41例住院使用抗精神病药物合并肝损害的患者随机分成两组,一组采用甘草酸二铵治疗,另一组给传统保肝降酶药,治疗12周,在治疗前及治疗后2、4、8、12周末观察其谷丙转氨酶(ALT)、谷草转氨酶(AST)指标变化、临床疗效、不良反应等。结果:治疗后甘草酸二铵组患者血清ALT、AST水平均明显降低,痊愈率占61.9%、总有效率95.2%,明显优于对照组,其治疗前后差异有统计学意义(P<0.05)。未见严重的不良反应。结论:甘草酸二铵治疗抗精神病药物所致肝损害是有效和安全的。

Effects of Diammonium glycyrrihizinate for patients with antipsychotic liver damage

Objective:To investigate the efficacy and safety of Diammonium glycyrrihizinate in treating antipsychotic liver damage.Methods:forty one patients with antipsychotic liver damage were randomly assigned to receive Diammonium glycyrrihizinate(n=21) or traditional hepatoprotectants(n=20) for 12 weeks.Hepatoprotective effect were primarily assessed by the activities of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) before treatment,the 2,4,8,12 weekend of treatment.Results: After treatment the activities of ALT and AST were significantly lower in patients treated with Diammonium glycyrrihizinate compared with those treated with traditional hepatoprotectants.The rates of cure(61.9%) and total effective(95.2%)in the Diammonium glycyrrihizinate treatment group were higher than the other one.No serious adverse events were reported during the study.Conclusions: Diammonium glycyrrihizinate administered is effective and safe for patients with antipsychotic liver damage.