Hydrallazine-induced Sj?gren's syndrome |
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| Authors: | A Darwaza P J Lamey J M Connell |
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| Institution: | Department of Oral Medicine and Pathology, Glasgow Dental Hospital and School, Scotland. |
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| Abstract: | 4 years after initiation of therapy with hydrallazine hydrochloride (for treatment of hypertension), a 60-year-old male patient developed clinical features of Sj?gren's syndrome, with immunological features of drug-induced systemic lupus erythematosus. In addition, the patient described rheumatoid arthritis-like symptoms and had reduced lacrimal and parotid salivary flow, but lacked the typical features of Sj?gren's syndrome on labial gland biopsy. 1 year after discontinuation of hydrallazine therapy, the clinical parameters returned to normal. |
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