Identification of Rv2041c, a Novel Immunogenic Antigen from Mycobacterium tuberculosis with Serodiagnostic Potential |
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| Authors: | S.-Y. Kim,A.-R. Shin&dagger ,&Dagger ,H.-J. Kim&dagger ,S.-N. Cho§ ,J.-K. Park&dagger ,¶ ,& S. J. Shin&dagger ,&Dagger |
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| Affiliation: | Renal Division, Department of Medicine, Peking University First Hospital;Institute of Nephrology, Peking University;Key Laboratory of Renal Disease, Ministry of Health of China;Beijing, China |
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| Abstract: | Factor H plays a key inhibitory role in control of the activation of alternative pathway of complement system. The aim of the study was to investigate the predictive value of factor H as a biomarker of renal injury in IgA nephropathy (IgAN). Urine factor H concentration from 202 patients was measured and compared with that of 60 healthy volunteers. Forty-eight patients fulfilled Haas-I or II (group 1), 60 fulfilled Haas-III (group 2) and 94 fulfilled Haas-IV or V (group 3). Co-deposition of factor H and C3b in kidneys were investigated using confocal microscope. The levels of urinary factor H, when expressed as a ratio of urinary creatinine, were significantly higher in groups 3 than group 1 and 2, also significantly higher in group 2 than group 1. In addition, the levels of urinary factor H were significantly higher in those with factor H deposition in the kidney than those without deposition. The levels of urinary factor H may be a useful biomarker to evaluate kidney injury in IgAN. |
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