伽玛刀分次治疗垂体泌乳素大腺瘤和巨腺瘤的近期疗效观察

目的　探讨伽玛刀分次治疗垂体泌乳素大腺瘤和巨腺瘤的近期疗效。方法　分别对 2 2例和 11例垂体泌乳素大腺瘤及巨腺瘤患者进行分次伽玛刀治疗及单次治疗 ,观察其治疗前后的临床症状、血清泌乳素 (PRL)水平、肿瘤体积等 ,分析伽玛刀分次治疗垂体泌乳素大腺瘤和巨腺瘤的近期疗效。结果　 2种方法治疗前后瘤体都有所缩小 ,PRL水平下降 ,分次治疗总有效率为 86 4% ,单次治疗总有效率为 45 5 % ,分次治疗对PRL水平的恢复明显优于单次治疗 (P <0 0 1) ;而对肿瘤大小的影响无显著差异 (P >0 0 5 )。结论　伽玛刀分次治疗垂体沁乳素大腺瘤和巨腺瘤是安全有效的治疗方法 ,其近期疗效明显优于伽玛刀单次治疗

THE OBSERVATION OF RECENT-TERM EFFICACY OF FRACTIONATED GAMMA KNIFE IN THE TREATMENT OF MACRO-PROLACTINOMA

Objective: To explore efficacy of fractioned gamma knife of macro-prolactinoma in the near future. Methods: 22 and 11 cases of macro-prolactinomas received the fractioned gamma knife and single-fraction gamma knife respectively. The efficacy of fractioned gamma knife was assessed by comparisons of clinical symptom, PRL value and volum of tumor between pretreatment and posttreatment. Results: After the treatment with two methods, the volum of prolactinoma and PRL were decreased. The effective rates with fractioned gamma knife and single-fraction gamma knife were 86.4% and 45% respectively. The impact of fractioned gamma on PRL was larger than single-fraction gamma knife (P<0.01), but impact on the volum of prolactinoma was no significant difference between fractioned knife gamma and single-fraction gamma knife (P>0.05). The effect of fractionated gamma knife was better than signle-fraction gamma knife (P<0.05). Conclusions: The fractioned gamma knife was safe and effective in the treatment of prolactinoma and its efficacy was significantly better compared to those treated with single-fraction gamma knife.