HLA Antigens and Nontuberculous Mycobacterial Lung Disease in Korean Patients |
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Authors: | Sang-Won Um Chang-Seok Ki O Jung Kwon Won-Jung Koh |
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Institution: | (1) Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Korea;(2) Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
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Abstract: | Background Human leukocyte antigen (HLA) molecules are known to play an important role in host-defense mechanisms. The aim of this study
was to evaluate the association between HLA alleles and lung disease caused by nontuberculous mycobacteria (NTM) in Korean
patients.
Methods Seventy-eight patients with NTM lung disease (48 patients with Mycobacterium avium-intracellulare complex MAC] infection and 30 patients with Mycobacterium abscessus infection) were included in the study. HLA-A, -B, and -DRB1 genotyping was performed by polymerase chain reaction using sequence-specific
primers. Data from 485 healthy Korean individuals were used as a control.
Results When compared to controls, patients with NTM lung disease showed an increased frequency of DRB1*11 (OR = 1.91, 95% confidence
interval CI] = 1.01–3.64, p = 0.045, corrected p pC] > 0.05). In the subgroup analysis, patients with MAC lung disease had an increased frequency of B*46 (OR = 2.23, 95%
CI = 1.05–4.73, p = 0.044, pC > 0.05).
Conclusions Our data suggest that in a Korean population, patients with NTM lung disease and healthy subjects differ in the frequencies
of some HLA alleles. However, when considering corrected p values, our findings are inconclusive.
S.-W. Um and C.-S. Ki contributed equally to this work. |
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Keywords: | Atypical mycobacteria Genetic predisposition to disease HLA antigens Mycobacterium avium-intracellulare infection |
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