4（R）—（6—氨基—9—嘌呤基）—2（R）—（羟甲基）四氢呋喃—3（R）—醇的合成

为寻找抗免疫缺陷病毒化合物，以D－核糖为原料，经甲基化、硅烷基化、还原裂解反应制得重要中间体1－脱氧核糖（5），再通过形成环状亚砜化合物，与NaN3发生反应后，经过还原、缩合、环合、氨化、脱保护基反应制得异脱氧腺嘌呤核苷（1），各步反应收率均超过70％。

Synthesis of 4(R)-(6-Amino-9H-Purine-9-yl)-2(R)- (Hydroxymethyl)Tetrahydrofuran-3(R)-ol

Deoxyribose(5),prepared from D-ribose via methylation,silylation and reductive cleavage,was converted into cyclic sulfite(7).The reaction of 7 with NaN 3 resulted in azide(8),which was converted into the isomeric deoxyadenosine 4(R)-(6-amino-9H-purin-9-yl)-2(R)-(hydroxymethyl)tetrahydrofuran-3(R)-ol(1)by a sequence of five high-yield reactions.