| 黄芪丹参对干燥综合征模型大鼠颌下腺的干预研究 |
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| 引用本文： | 林〓青,张前德.黄芪丹参对干燥综合征模型大鼠颌下腺的干预研究[J].南京医科大学学报,2010(4):454-457. |
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| 作者姓名： | 林〓青 张前德 |
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| 作者单位： | 南京医科大学第一附属医院中医科; |
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| 基金项目： | 江苏省教育厅资助课题(07kjb360073);;江苏省科技厅国际合作计划资助课题(BR2006058) |
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| 摘 要： | 目的:观察中药黄芪合并丹参组成的小复方对干燥综合征模型大鼠颌下腺的干预。方法:提取Wistar同种大鼠颌下腺组织后匀浆与完全弗氏佐剂(CFA)混匀乳化,注射大鼠两后脚掌与两侧腹股沟皮下,然后在背部皮下注射百白破联合疫苗加强免疫,产生近似于人类干燥综合征唾液腺的病理改变及临床表现。应用中药颗粒黄芪合并丹参干预进行疗效观察。结果:模型大鼠免疫制备7W,唾液流量减少(P<0.05),体重明显减轻(P<0.05),颌下腺指数增加(P<0.05)。黄芪合并丹参对模型鼠部分观察指标有改善,造模中药复方低、高剂量组能明显增加唾液流量(P<0.05),增加体重(P<0.01),但是饮水量与造模后生理盐水对照组没有统计学意义(P>0.05)。结论:黄芪合并丹参小复方对复制干燥综合征模型鼠有增加体重、增加唾液分泌量的作用。
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| 关 键 词： | 干燥综合征 病理模型 大鼠 中药干预 唾液腺 |
| 收稿时间： | 2009/11/23 0:00:00 |
Effects of Astragalus Danshen on rat submandibular gland in Sjogren's syndrome model:an intervention study |
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| LIN Qing and ZHANG Qian-de.Effects of Astragalus Danshen on rat submandibular gland in Sjogren's syndrome model:an intervention study[J].Acta Universitatis Medicinalis Nanjing,2010(4):454-457. |
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| Authors: | LIN Qing and ZHANG Qian-de |
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| Institution: | Departmentof Traditional Chinese Medicine/a>;the First Affiliated Hospital of NJMU/a>;Nanjing 210029/a>;China |
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| Abstract: | Objective:To observe the interventive effects of Astragalus Danshen compound on rat submandibular gland in a small model of Sjogren's syndrome. Methods:Submandibular gland tissue was extracted from Wistar rat,and emulsificated with complete Freund's adjuvant (CFA)after blending,then subcutaneously injected into the rats on the hind feet and both sides of the groin. After that,subcutaneous injection of DTP vaccine was performed on the back to enhance immunity,thus producing pathological changes and clinical ... |
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| Keywords: | Sjogren's syndrome pathological model rat medicine intervention salivary |
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