| 肿瘤多药耐药逆转剂的研究进展 |
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| 引用本文： | 戴春岭,符立梧. 肿瘤多药耐药逆转剂的研究进展[J]. 中国药理学通报, 2005, 21(5): 513-518 |
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| 作者姓名： | 戴春岭 符立梧 |
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| 作者单位： | 中山大学肿瘤防治中心,广东,广州,510060 |
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| 基金项目： | 广东省自然科学基金，国家自然科学基金 |
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| 摘 要： | 肿瘤细胞产生的多药耐药(multidrugresistanceMDR)已成为当前影响肿瘤化学治疗疗效的主要障碍。尽管MDR产生机制复杂,但是由mdr1基因编码的P糖蛋白(PglycoproteinPgp)的过表达是产生MDR的主要原因。寻找低毒有效的MDR逆转剂是提高化疗疗效的一个重要方法,是化疗领域亟需解决的问题。
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| 关 键 词： | 多药耐药 P-糖蛋白 逆转剂 肿瘤 治疗 |
| 文章编号： | 1001-1978(2005)05-0513-06 |
| 修稿时间： | 2004-10-18 |
The development of the reversal of the tumor multidrug resistance |
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| DAI Chun-ling,FU Li-Wu. The development of the reversal of the tumor multidrug resistance[J]. Chinese Pharmacological Bulletin, 2005, 21(5): 513-518 |
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| Authors: | DAI Chun-ling FU Li-Wu |
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| Abstract: | Multidrug resistance(MDR)of tumor cells has become the main impediment that influence the curative effect of cancer chemotherapy. Although there are many mechanisms can generate the multidrug resistance, the overexpression of P-glycoprotein encoded by the multidrug resistance-1(mdr1) gene is the main cause in the formation of MDR. Seaching for innocuous and effective reversal of MDR is not only a method of improving the efficiency of cancer chemotherapy but also the problem desiderated to be resolved in chemotherapy domain. |
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| Keywords: | multidrug resistance P-glycoprotein reversal tumor therapy |
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