阴虚阳虚大鼠模型PO/AH温度敏感神经元放电变化的观察

为了研究阴虚阳虚状态下体温中枢调节过程是否受到影响,本文采用微电极细胞外记录方法观察阴虚和阳虚大鼠模型视前区—下丘脑前部(PO/AH)温度敏感神经元放电变化,发现阴虚大鼠冷敏神经元比例上升,阳虚大鼠热敏神经元比例上升,两者的神经元构成比与对照组相比,差异有显著性(X~2=18.41,P<0.01),阴虚和阳虚组神经元平均放电频率都低于对照组,神经元对热刺激的耐受性也低于对照组。以上结果提示:阴虚和阳虚大鼠体温中枢调节功能有一定程度下降,并伴有产热一散热失衡。

Spike Discharge Changes of PO/AH Thermo-sensitive Neuron(TSN) in Yin-deficient and Yang-deficient

In order to investigate whether the process of central thermoregulation is affected in the state of yin-deficiency and yang-deficiency, an experiment was conducted to observe the thermosensitive neuron (TSN) discharges of preoptic anterior hypothalamus (PO/AH) in yin-deficient and yang-deficient rat patterns with a microelectrode extracellular record- ing method. It was found that there was an increased ratio in cold-sensitive neurons (CSN) of yin-deficient group and in warm-sensitive neurons (WSN) of ying-deficient group respectively, and there was a significant difference of neuron proportion between the two groups and the control group (X~2=18.41, P<0.01). Compared with normal rats, the average discharge frequency and the tolerance of neuron to warm stimuli were lower respectively. These results suggest that the central thermoregulatory function, to some extent, is damaged and the inequilibrium between heat-production and heat-dissipation occurs in yin-deficient and yang-deficient rats.