Spontaneous expression of endogenous type C RNA virus by BALB/c splenic B lymphocytes in continuous culture. |
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Authors: | E Premkumar-Reddy P J Price C J Heilman P S Sarma |
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Affiliation: | 1. Microbiological Associates, 5221 River Road, Bethesda, Maryland 20014, USA;2. National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA |
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Abstract: | B-lymphocyte cultures were established from spleens of BALB/c, C57B1/6, NIH Swiss, and SWR mice of various age groups. Spontaneous, consistent, and thus predictable release of a B-tropic mouse endogenous virus occurred from the very first passage in cultured lymphocytes derived from BALB/c mice 6 months old or older but not from similar lymphocytes derived from BALB/c mice of 1.5 or 3 months of age. C57Bl/6, NIH Swiss, and SWR mice belonging to various age groups ranging between 1.5 and 18 months failed to exhibit such a spontaneous release of viral particles. We conclude that in BALB/c splenic B lymphocytes a breakdown of cellular control mechanisms occurs in older animals leading to viral production while such a phenomenon is absent in C57Bl/6, NIH Swiss, and SWR mice. |
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Keywords: | To whom reprint requests should be addressed. |
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