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| 神经发育危险因素与精神分裂症发病的关系 | |
| 引用本文： | 邓红,刘协和,蔡贵庆,孙学礼,侯再金,羊礼军,尹承德,曹华琼,聂兵,韩海英,王泽旭,袁有才,熊骊龙,宋天才,梁晓苏,蔡作义,简光媛,何军,熊学智,胡隆珊,黄问一,王忠禹,黄健,苏里成.神经发育危险因素与精神分裂症发病的关系[J].中华精神科杂志,2001,34(1):9-12. |
| 作者姓名： | 邓红 刘协和 蔡贵庆 孙学礼 侯再金 羊礼军 尹承德 曹华琼 聂兵 韩海英 王泽旭 袁有才 熊骊龙 宋天才 梁晓苏 蔡作义 简光媛 何军 熊学智 胡隆珊 黄问一 王忠禹 黄健 苏里成 |
| 作者单位： | 1. 华西医科大学附属第一医院心理卫生研究所 2. 四川省精神卫生中心 3. 重庆市第二精神病院 4. 四川省元通荣校 5. 四川省内江白马精神病院 6. 四川省内江市第二人民医院 7. 四川省泸州市精神卫生中心 8. 四川省资阳市精神病院 9. 四川省自贡市精神病院 10. 成都市第四人民医院 |
| 摘 要： | 目的探讨神经发育危险因素与精神分裂症发病的关系。方法采用病前分裂样及分裂型特质量表（PSST）和病前社会适应量表（PSA），对166个家系中的310例精神分裂症患者（患者组）及307名正常同胞（对照组）进行评定和病例-对照研究，并将所有研究对象以PSST和PSA评分按照1/3位数划分为高分组、中分组、低分组进行比较。对两组神经发育危险因素进行单因素及多因素Logistic回归模型分析。结果（1）经病例-对照分析，高热惊厥及婴幼儿期患严重疾病与精神分裂症的发生有关［比数比（OR）值分别为6.05和2.64，P值为0.02和0.01］；经多因素Logistic回归模型分析，亦提示这两个因素与精神分裂症的发病有关（高热惊厥的OR=4.7，P=0.06，婴幼儿期患严重疾病的OR=2.7，P=0.02）。（2）高热惊厥、婴幼儿期患严重疾病与PSST和/或PSA高分数有一定关系。PSST及PSA的高分和中分者患精神分裂症的机会较低分者增加（P<0.001）。结论高热惊厥及婴幼儿期患严重疾病可能增加精神分裂症的易感性，这两个因素可能与儿童、青少年期的个性和社会适应不良有关。 |
| 关 键 词： | 精神分裂症 危险因素 发育障碍 回归分析 |
A study of the relationship between neurodevelopment risk factors and the susceptibility of schizophrenia |
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| DENG Hong,LIU Xiehe,CAI Guiqing,et al Institute of Mental Health,First University Hospital,West China University of Medical Sciences,Chengdu ,China.A study of the relationship between neurodevelopment risk factors and the susceptibility of schizophrenia[J].Chinese Journal of Psychiatry,2001,34(1):9-12. | |
| Authors: | DENG Hong LIU Xiehe CAI Guiqing Institute of Mental Health First University Hospital West China University of Medical Sciences Chengdu China |
| Institution: | DENG Hong,LIU Xiehe,CAI Guiqing,et al Institute of Mental Health,First University Hospital,West China University of Medical Sciences,Chengdu 610041,China |
| Abstract: | Objective To study the relationship between neurodevelopment risk factors and the susceptibility of schizophrenia Methods Three hundred and ten schizophrenic patients and their 307 normal sibs coming from 166 families were studied Univariable and multivariable logistic regression analyses were performed to explain the relationship between neurodevelopment risk factors and schizophrenia Results (1) Univariable and multivariable logistic regression analyses showed that febrile convulsion and severe somatic disease during early childhood were related to the susceptibility of schizophrenia With univariable analysis, the correlation between febrile convulsion and schizophrenia showed OR =6 05, P =0 02, severe disease showed OR =2 64, P =0 01; With multivariable analysis, febrile convulsion showed OR =4 7, P =0 06, severe disease showed OR =2 7, P =0 02 (2) Febrile convulsion and severe disease were related to high scores of PSST and/or PSA Comparing to the individuals with low scores of PSST and PSA, individuals with high and middle score showed higher risk of schizophrenia, P <0 001 Conclusion Febrile convulsion and severe disease during early childhood may increase the susceptibility of schizophrenia On the other hand, febrile convulsion and severe disease may be related to the personality traits and social adjustment disorders in childhood and early adolescent, and such disorders may be related to the susceptibility of schizophrenia |
| Keywords: | Schizophrenia Risk factors Developmental disabilities Regression analysis |
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