| 丹皮酚-β-环糊精包合物结肠定位释药片剂的制备 |
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| 引用本文： | 王通艳,崔启华,曹青日,崔京浩.丹皮酚-β-环糊精包合物结肠定位释药片剂的制备[J].中国中药杂志,2011,36(21):2956-2959. |
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| 作者姓名： | 王通艳 崔启华 曹青日 崔京浩 |
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| 作者单位： | 苏州大学药学院药剂学教研室,江苏苏州,215123 |
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| 基金项目： | 科技部国际科技合作项目(2009DFA31330);国家"重大新药创制"科技重大专项(2009ZX09502-009) |
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| 摘 要： | 目的:制备丹皮酚-β-环糊精包合物( Pae-β-CYD)的结肠定位释药片剂.方法:以Pae-β-CYD,果胶,乙酸钙作为片芯,Eudragit S100乙醇溶液包衣,考察包衣增重、增塑剂用量、熟化时间与温度等因素对包衣片体外释药的影响.结果:包衣增重为12％,增塑剂用量为20％时,熟化温度为45℃,熟化时间为12 h,Pae-β-CYD片剂在果胶酶或大鼠结肠内容物中的释药时滞为5～6h.结论:Pae-β-CYD结肠定位释药片剂显示pH环境和酶降解依赖释药特征.
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| 关 键 词： | 丹皮酚 β-环糊精 包合物 结肠靶向 |
| 收稿时间： | 2011/3/29 0:00:00 |
Preparation of paeonol-beta-cyclodextrin inclusion complex loaded colon specific delivery tablets |
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| WANG Tongyan,CUI Qihu,CAO Qingri and CUI Jinghao.Preparation of paeonol-beta-cyclodextrin inclusion complex loaded colon specific delivery tablets[J].China Journal of Chinese Materia Medica,2011,36(21):2956-2959. |
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| Authors: | WANG Tongyan CUI Qihu CAO Qingri and CUI Jinghao |
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| Institution: | Department of pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China;Department of pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China;Department of pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China;Department of pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China |
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