| 慢性丙型肝炎患者自身免疫现象的初步研究 |
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| 引用本文： | 周东辉,黄祖瑚.慢性丙型肝炎患者自身免疫现象的初步研究[J].中华传染病杂志,1995,13(1):8-10. |
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| 作者姓名： | 周东辉 黄祖瑚 |
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| 作者单位： | 南京医科大学一附院 |
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| 摘 要： | 作者对４８例慢性丙型肝炎（丙肝）、３０例慢性乙型肝炎（乙肝）患者及２０例健康人分别检查了血清ＡＮＡ、ＳＭＡ和抗－ＧＯＲ。结果慢性丙肝组血清自身抗体（ＡＮＡ／ＳＭＡ）阳性率为３３．３％（１６／４８），明显高于健康人组的５％（１／２０）（Ｐ〈０．０２５）。在输血后慢性丙肝和散发性慢性丙肝中，ＡＮＡ／ＳＭＡ阳性率分别为２５．６％和６６．７％（Ｐ〈０．０５），ＡＮＡ／ＳＭＡ平均滴度分别为１：２０和１：１０
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| 关 键 词： | 丙型肝炎病毒 自身免疫 丙型肝炎 自身抗体 |
PRELI MI NARY STUDY ON AUTOIMMUNE MANIFESTATION INPATIENTS WITH CHRONIC HEPATITIS C |
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| Zhou Donghui,Hiang zuhu,Jia Fuzhong.PRELI MI NARY STUDY ON AUTOIMMUNE MANIFESTATION INPATIENTS WITH CHRONIC HEPATITIS C[J].Chinese Journal of Infectious Diseases,1995,13(1):8-10. |
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| Authors: | Zhou Donghui Hiang zuhu Jia Fuzhong |
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| Institution: | Zhou Donghui,Hiang zuhu,Jia Fuzhong. The First Affiliated Hospital of Nanjing Medical Univeity Nanjing,210029 |
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| Abstract: | era from 48 patients with chronic hepatitis C(CHC)(39 cases were posttrans-fusion case,9 cases were sporadic case)and from 30 cases with chronic hepatitis B (CHB)as well as 20 healthy persons had been tested for ANA, SMA and anti-GORby using immunofluorescence technique(IFT) and ELISA, respectively. Frequency ofANA/SMA in CHC group was 33.6%(16/48) which was significantiy higher than5%(1/20) in the healthy person group (P<0.025). Between subgroup of post- transfusion case and sporadic case of CHC,frequency and mean titer of ANA/SMA were 25.6% vs 66. 7%(P<0.05)and l:20 vs l:100(P<0.001),respectivety. Posi- tive rate of anti-GoR in CHC,CHB and healthy person group was 58. 3%,3.3%and0%respectuvely,it indicates that anti- GOR was closely related to HCV infection(P<.005).These results suggest that: HCV infection trigger off the autoimmune reaction,cspecially in sporadic cases. |
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| Keywords: | Hepatitis C virus Anti-GOR Autoimmune hepatitis |
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