我院405例药品不良反应报告分析

目的:了解我院药品不良反应(ADR)的发生特点。方法:对我院2004年1月1日～2006年6月15日收集到的405例ADR报告分别从药品种类、临床表现、给药途径及患者年龄等方面进行统计、分析。结果:405例ADR中,涉及抗感染药191例(47．16％)、中药注射剂141例(34．81％);≥60a有216例(53．33％);静脉滴注引起的ADR 283例(69．88％);皮肤及其附件损害有16例(41．23％)。结论:应合理使用抗感染药及中药注射剂,加强对中药注射剂的质量监测,避免或减少ADR重复发生。

Analysis of 405 ADR Reports in Our Hospital

OBJECTIVE: To investigate the features of adverse drug reaction(ADR) incidence for rational use of drugs. METHODS:405 ADR case reports were collected from our hospital,spanning Jan.1. ,2004 to Jun.15. ,2006.The reports were analyzed in terms of therapeutic category, clinical manifestation, administration route and patient age.RESULTS: Of the 405 ADR cases, 191 cases(47.16%) were associated with antiinfectives, and 141 cases(34.81%) with TCM injections; 216 cases (53.33%) were received in patients aged 60 or up; 283 cases(69.88% ) were caused by intravenous administration; 16 cases (41.23%) were reported on the skin and local lesion.CONCLUSION: Antiinfectives and TCM injections should be used rationally, and quality control over TCM injections should be tightened so as to avoid or minimize repeat incidence of ADR cases.