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Anti-angiogenic activity of the methanol extract and its fractions of Ulmus davidiana var. japonica |
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| Authors: | Jung Hyun-Joo Jeon Hye-Jin Lim Eun-Ju Ahn Eun-Kyoung Song Yun Seon Lee Sanghyun Shin Kuk Hyun Lim Chang-Jin Park Eun-Hee |
| Institution: | College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Republic of Korea. |
| Abstract: | This study aimed to elucidate anti-angiogenic activity of Ulmus davidiana var. japonica that has been widely used in folk medicine. The methanol extract (UDE) of Ulmus davidiana var. japonica concentration-dependently displayed a strong inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. The n-butanol fraction of UDE and subsequent 30% MeOH subfraction were identified to be most responsible for the anti-angiogenic activity. |
| Keywords: | Ulmus davidiana var japonica Angiogenesis Anti-angiogenic Chorioallantoic membrane Ulmaceae |
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