The relationship of three-dimensional joint space width on weight-bearing CT with pain and physical function |
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Authors: | Mayank D. Kothari Kaitlin G. Rabe Donald D. Anderson Michael C. Nevitt John A. Lynch Hayden Franz Neil A. Segal |
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Affiliation: | 1. Department of Rehabilitation Medicine, The University of Kansas, Kansas City, Kansas;2. The University of Texas at Dallas, Richardson, Texas;3. Department of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, Iowa;4. UCSF Department of Epidemiology & Biostatistics, The University of California, San Francisco, San Francisco, California |
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Abstract: | Limitations of plain radiographs may contribute to poor sensitivity in the detection of knee osteoarthritis and poor correlation with pain and physical function. Three-dimensional (3D) joint space width (JSW), measured from weight-bearing computed tomography (CT) images, may yield a more accurate correlation with patients’ symptoms. We assessed the cross-sectional association between 3D JSW and self-reported pain and physical function. Five hundred twenty eight knees (57% women) were analyzed from Multicenter Osteoarthritis Study participants. An upright weight-bearing CT scanner was used to acquire bilateral, weight-bearing, fixed-flexion images of the knees. A 3D dataset was reconstructed from cone beam projections and JSW was calculated across the joint surface. The percentages of the apposed medial tibiofemoral joint surface with JSW less than 2.0 and 2.5 mm, respectively, were calculated. Pain and physical function were measured using Western Ontario and McMaster Universities Osteoarthritis Index. Participants who reported greater pain severity tended to have a greater joint area with JSW less than 2.0 mm (P = .07 for the highest vs the lowest tertile). Participants who reported greater functional limitations had a greater joint area with JSW less than 2.0 mm (P = .02 for the highest vs the lowest tertile). There appears to be an association between the medial tibiofemoral area with JSW less than 2.0 mm and pain and physical function. |
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Keywords: | arthralgia imaging knee joint physical function three-dimensional |
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