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Decreased Penetrance of Parkinson's Disease in Elderly Carriers of Glucocerebrosidase Gene L444P/R Mutations: A Community-Based 10-Year Longitudinal Study |
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| Authors: | Shaozhen Ji PhD Chaodong Wang MD PhD Hongwen Qiao PhD Zhuqin Gu PhD Ziv Gan-Or MD PhD Edward A. Fon MD FRCP(C) Piu Chan MD PhD |
| Affiliation: | 1. Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China;2. Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China Clinical and Research Center for Parkinson's Disease, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China;3. Department of Nuclear Medicine, Xuanwu Hospital of Capital Medical University, Beijing, China Department of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China;4. Clinical and Research Center for Parkinson's Disease, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China;5. Montreal Neurological Institute and Hospital, Department of Neurology & Neurosurgery, McGill University, Montreal, Canada;6. Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China |
| Abstract: | |
| Keywords: | community-dwelling older adults GBA L444P mutation heterozygotes Parkinson's disease risk |