Melatonin phase advances circadian rhythm |
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Authors: | M. E. J. Attenburrow B. A. Dowling P. A. Sargent A. L. Sharpley P. J. Cowen |
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Affiliation: | (1) University Department of Psychiatry, Littlemore Hospital, OX4 4XN Oxford, UK |
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Abstract: | We studied the effect of acute (1 day) and subacute (7 days) treatment with melatonin (0.5 mg) on the endogenous rhythms of melatonin secretion in 12 healthy male volunteers, using a placebo-controlled, double-blind, cross-over design. Melatonin given at 1700 h for 7 days significantly advanced the onset of endogenous melatonin secretion, while a single dose was without effect. These data are consistent with the hypothesis that melatonin plays a role in the organisation of circadian rhythms in humans and suggests that appropriately timed melatonin administration may provide a means of altering the timing of circadian cycles. |
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Keywords: | Melatonin Circadian rhythm |
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