| 细胞间黏附分子-1基因K469E多态性与缺血性卒中 |
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| 引用本文： | 孙沄,李洪军,张晨. 细胞间黏附分子-1基因K469E多态性与缺血性卒中[J]. 国际脑血管病杂志, 2004, 12(10): 785-787 |
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| 作者姓名： | 孙沄 李洪军 张晨 |
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| 作者单位： | 青岛大学医学院附属医院神经内科研究生;266003,青岛大学医学院附属医院神经内科 |
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| 摘 要： | 细胞间黏附分子 1(ICAM 1)参与动脉粥样硬化的发生和发展 ,是缺血性卒中的重要发病机制之一。ICAM 1基因K4 6 9E多态性与缺血性卒中的关系日益受到重视。研究表明 ,EE基因型明显增加卒中的危险性。
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| 关 键 词： | 细胞间黏附分子-1 多态性 缺血性卒中 |
| 修稿时间： | 2004-07-20 |
Intercellular Adhesion Molecule-1 Gene K469E Polymorphism and Ischemic Stroke |
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| Sun Yun ,,Li Hongjun,Zhang Chen. Intercellular Adhesion Molecule-1 Gene K469E Polymorphism and Ischemic Stroke[J]. International Journal of Cerebrovascular Diseases, 2004, 12(10): 785-787 |
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| Authors: | Sun Yun Li Hongjun Zhang Chen |
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| Affiliation: | Sun Yun 1,2,Li Hongjun1,Zhang Chen2 1Department of Neurology,Shengbei Hospital,Shengli Oil Field,Dongyi ng 257064,China, 2Department of Neurology,the Affiliated Hospital of Qingda o University Medical College,Qingdao 266003,China |
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| Abstract: | Intercellular adhesion molecule-1 involves in the formation and development of atherosclerosi s, so it plays an important role in the pathogenesis of ischemic stroke. The rel ationship between the K469E polymorphism of the ICAM-1 gene and ischemic stroke is being appreciated increasingly. Studies have indicated that EE genotype may significantly increase the risk of ischemic stroke. |
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| Keywords: | intercellular adhesion molecule-1 polymorphism ische mic stroke |
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