The preparation of 11C-labelled fluoromethane for the study of regional cerebral blood flow using positron emission tomography期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The preparation of 11C-labelled fluoromethane for the study of regional cerebral blood flow using positron emission tomography

Authors:	Dr. Sharon Stone-Elander Per Roland Lars Eriksson Jan-Eric Litton Peter Johnström Lennart Widen

Affiliation:	(1) Karolinska Pharmacy, Box 60024, S-10401 Stockholm, Sweden;(2) Department of Clinical Neurophysiology, Karolinska Hospital, S-10401 Stockholm, Sweden;(3) Department of Neuroradiology, Karolinska Hospital, S-10401 Stockholm, Sweden;(4) Department of Psychiatry and Psychology, Karolinska Hospital, S-10401 Stockholm, Sweden

Abstract:	Fluoromethane, previously labelled with ¹⁸F and used as a tracer in the measurement of regional cerebral blood flow, was ¹¹C-labelled by the reaction of ¹¹C-methyl iodide with tetraethylammonium fluoride. Sufficient quantities of radiotracer were prepared with a minimum amount of handling from 15 min target irradiations in the ¹⁴N(p, ) ¹¹C reaction. Total synthesis time was 25 min from end-of-bombardment, allowing serial blood flow measurements 30 min apart. The use of ¹¹C-fluoromethane as a cerebral blood flow tracer in positron emission tomography is discussed.

Keywords:	¹¹C-labelled fluoromethane Cerebral blood flow Positron emission tomography
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